Exploring Unconventional Plant-Derived Metabolites to Keep Away Diabetes: The case of Pomegranate

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  • 60726088-4828-4505-a34e-6c2a6a218866
  • Exploring Unconventional Plant-Derived Metabolites to Keep Away Diabetes: The case of Pomegranate
  • EXPLORER
  • FAZER+/ILIND/CBIOS/1/2023
  • 2023-06-01
  • 2026-06-30
  • Past
  • EXPLORER proposes the development of a human intervention study to
    evaluate the effect of ellagitannin-rich pomegranate supplements in the
    metabolic and β-cells functional markers, IAPP aggregation risk, urolithin B
    (UroB) circulating levels, and microbiota status in individuals with pre-diabetes
    to test the hypothesis that UroB is the bioactive molecule improving metabolic
    health via mitigation of IAPP cytotoxicity. Given the poor UroB bioavailability
    and scarcity of information on its tissue distribution, an innovative
    nanotechnology solution, followed by the required safety studies, is proposed to
    ensure the proper delivery of the molecule to β-cells in the pancreatic tissue.
    With this experimental design, the team expects to overcome the limitations
    associated with the low circulating concentrations of UroB provided by the diet.
    A powerful Science Communication plan was designed to efficiently
    disseminate the findings for stakeholders at the community, academia, and
    industry levels, to improve literacy about diabetes and mainly its prevention.
  • Lusófona University
  • https://research.ulusofona.pt/en/projects/60726088-4828-4505-a34e-6c2a6a218866
    • Lusófona University
    • Usf São Martinho De Alcabideche
    • Cicant - Centre For Research In Applied Communication, Culture, And New Technologies
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