The project “360 Refugees - the challenges of sheltering” - is a transdisciplinary exploratory project that aims to develop and test an immersive experience on the challenges of local communities in welcoming refugees.
The story will be created by capturing 360-degree videos, making a contemporary connection about the history of reception in Portugal, with the receipt of refugee families from war regions, who are already installed in the country, bringing light to the challenges and adversities of this change.
The objective is to create a reflection on the theme, which is so sensitive in the community, since it is necessary to create a more empathetic and solidarity culture for those who need help to start over.
For this, a 360-degree documentary will be created to promote immersion in the subject, an exhibition and an interactive website that can collaborate for the dissemination of information and help to create a culture of empathy and welcome in young Portuguese people.
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A computationally assisted drug development pipeline for challenging cancers with very few effective therapeutic options
No Acronym
FCT
2024-05-29
2025-05-28
Past
This HPC project corresponds to the second part of the computational working package of the project 2022.05718.PTDC, already approved by FCT (“Exploiting monoterpene indole alkaloid derivatives for overcoming resistance in BRCA-deficient cancers. In silico characterization of binding modes”).
The group of Prof. Maria J.U Ferreira (Co-PI; imed/FFUL) identified a monoterpene indole alkaloid derivative (BBIT20) with the ability to target homologous recombination DNA repair defects by disrupting the BRCA1-BARD1 heterodimer in triple-negative breast and ovarian cancer cells. The BRCA1 and BARD1 proteins, both involved in homologous recombination, have been associated with altered DNA repair mechanisms in several different types of cancer, such as pancreatic tumors, advanced ovarian and triple-negative breast cancer. BBIT20 showed promising in vitro and in vivo antitumor activity while in synergistic interaction with PARP inhibitor Olaparib and cisplatin. BBIT20 is patented and is the first reported disrupter of the BRCA1-BARD1 complex and may be a strong starting point for the continued development of new anticancer agents against the harder to treat cancers with very few effective therapeutic options.
The goals of this project are to find the BBIT20’s binding mode and thereafter allow the guided development of new effective plant-derived alkaloids capable of reversing drug resistance in cancer cells, through disruption of the BRCA1-BARD1 complex. BBIT20’s binding mode will be characterized through computational approaches. The binding hot spots were already identified by molecular docking in the first part of the running FCT project. Now, in this HPC project, molecular dynamics will help understand the type of interaction and mode of action. A rational for the molecular derivatization of compounds for the phytochemical studies will be established, that will help to clarify structure-activity trends and the design of novel analogs with improved binding capability.
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A nanotechnological approach for topical administration of insulin for wound healing
NANO WOUND
FCT
2018-08-01
2021-08-01
Past
The main aim of this project is to develop a nanotechnological-based product for insulin delivery, for improvement of wound healing and treatment of wound-related problems, improving the patients quality of life.
a new antibacterial scaffold and biological applications
Nipharmin
2018-01-01
2019-12-31
Past
The Nipharmin aim is to increase the potency of Nipharmins and to develop Nipharmin-based antibacterial technologies. In this context, the synthesis of new derivatives and further studies for understanding their mechanism of action are necessary. We formed a multidisciplinary team to develop this new family of antibacterials and to investigate their potential in biotechnological applications.
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A Systemic APproach to social media and pre-adolescents through thinking skills education
ASAP
KA220-SCH-BC59D668
Erasmus +
2022-09-01
2025-08-31
Past
The already significant digital transformation experienced over the last 30 years has been given a strong boost by the COVID-19 pandemic. Today’s school kids are not only digital natives; they were also forced for almost two years to move most of their daily learning and relational activities to online platforms. Digital spaces are, therefore, increasingly institutionalised even among children and in the school context.
ASAP addresses digital transformation from the onset age by fostering a conscious use of digital and social media in kids (namely pre-adolescents). The project works on metacognitive skills aiming to develop the kids’ understanding of how media shape and transform the relation between the inner and the outside world. Digital transformation will not end; therefore, kids need to develop skills related to awareness, metacognition, and abstraction, linked to thought and critical thinking, thus building resilience and capacity to feel at home in changes. Also, ASAP aims at the creation of a school community speaking not only through social media but also about social media.
ASAP addresses several Key Competences, i.e. Digital, Literacy, Personal & Social, Citizenship, Cultural Awareness & Expression competences. Most importantly it addresses Learning to Learn; metacognition, indeed, strengthens the kids’ ability to think about their actions on social media and prevent impulsive behaviour and disquiet in surfing on the internet.
The activities conducted within the project start from what students already know about social media, and the motivation and curiosity that drive every kid on the web. By doing that, ASAP will work on the awareness of dangers and hazards of the digital realm and the psychological aspects involved in the use of social media, which can lead to phenomena such as cyberbullying or exclusion. It also considers the major role that educators (teachers or families) play and the need for proper training so that they are able to guide reflection on the media.
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A Virtual Solution for a comprehensive and coordinated training for Foreign Language Teachers in Europe
VIR_TEACH
2018-1-ES01-KA203-050045
2018-09-01
2021-08-31
Past
According to recent studies developed by the European Commission, there is an urgent need to improve Initial Teacher Education (ITE) to make it more attractive, collaborative and system-wide focused.
Some of the detected competencies and selection, short term vision and poor evaluation system performance. VIR_TEACH is a step forward to advance on the previous work developed by other networks that have been pursuing the internationalisation of educational practice.
While the labour mobility of this sector is in continuous growth, there is no unified format for teacher training at European level. Neither the digital platforms for promoting mobility, nor unified digital tools for the mentoring the needs of students in their internship phase.
The creation of the digital space suggested in VIR_TEACH (A Virtual Solution for a comprehensive and coordinated training for foreign language TEACHers in Europe) project would foster the internationalization and convergence of national formats, as well as the exchange of methodologies and good practices. The objectives are:
To design of user-friendly and useful digital tools aimed at ITE, focused on knowledge transfer, social networking and follow-up during the internship phase. To research into a coherent competencies framework and the broad outlines of institutional action. To promote the sharing of innovative practices in the initial training of language teachers and the internationalization of the respective training practices, progressing towards the European Convergence The transnational cooperation required for the development of this project will ensure the exchange of best policies in ITE. The target groups involved in this project are universities and secondary and language schools from the participating countries, policy makers, trainee-teachers, policy makers and national representatives.
This project would provide a compendium of good practices and resources for trainee-teachers (O1).
It would create a digital space of encounter and exchange between the teacher trainers, the students and the pre-service and in-service centers, providing in addition a digital space to enhance a greater coherence between the training and the internship phase (O2).
A series of guidelines will be published, specifically for public administrators (O3).
Also, two events will be organised, to disseminate these outputs and collect feedback: An International Workshop and Formative Evaluation and the First European Conference on Foreign Languages Teachers Training.
Furthermore, the Project will suppose:
Higher degree of internationalisation of foreign language trainee-teachers; Improved knowledge transfer and dissemination of resources and Best Practices and specific adaptation of tools and resources adapted to each national context; More integrated follow-up the pre-service and in-service teacher training phases; Enhanced and systematic protocol for professional competencies in the fields of teaching, didactics of foreign languages and peer-communication/peer-learning; Improvement of Best Practices exchange through the creation of a wide and transnational community of education professionals and trainee-teachers in the fields of foreign languages. This online communication will enjoy a great scope at long-term for implementing new masters and postgraduates exchange and internationalisation programmes; Secondary Education is a crucial stage for assessing the Quality of the Formal Education systems in Europe. Foreign Language teachers training and procedures for accessing this profession is a key factor to ensure the formal education system follows the highest quality standards and does it in convergence with all European countries. VIR_TEACH aims to raise and homogenise the required competencies for an efficient and high-quality teaching labour at Secondary Education stages, developing methodologies and systematic analysis of the current situation in the EU and deploying a set of resources for taking the right steps and progress steadily in the right direction.
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Abietane Cationic Amphiphiles (ACA) to tackle resistant bacteria
ACA
2020-01-01
2021-01-01
Past
This project focused on the development of novel abietane cationic amphiphiles (ACAs) by chemical modification of dehydroabietic acid (DHA), leading to cationic amide derivatives by condensation of the DHA carboxyl function with the amine group of biogenic polyamines (spermine) and basic proteinogenic amino acids (arginine). The presented project performed a screening of antimicrobial activities of the compounds DHA and ACA hemi synthesis intermediary (ACA-Int) against a collection of Gram-positive, Gram-negative bacteria and yeasts; toxicological studies to assess if the compounds had antimicrobial and not citotoxic properties; and microencapsulation and stability studies to evaluate the chemical behavior and stability of the tested compounds.
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Activism in Collaborative Networks and Platforms The case of the activisms and platforms that emerged with the 2017 fires (Portugal)
Ativismo em Rede e Plataformas Colaborativas
CICANT/Researcher/2019
Institutional Funding
2020-01-01
2022-01-31
Past
The project proposes to study the activisms related to the major fires that hit Portugal, in particular the inner Central region, June 17 and following days and October 15 and 16, 2017. It aims to identify, characterize and analyze the collaborative digital platforms that instituted alternative public spaces and new forms of collective and political action. Given that the use of networked digital technologies by netactivists relies on a new type of reticular sociability that develops in connected digital social networks and participatory media, in which the possibilities of unlimited expression and dissemination of messages are used for new modes of interaction, association, and mobilization (whether protest or other civic mobilizations), we intend to analyze the new modes of communication, sociality, and mobilization that create alternative public spaces and new forms of social and political intervention.
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Based on the aural experience in two parishes of the municipality of Lisbon, Alvalade and Belém, we intend to draw the relationship of the communities with their neighbourhood.
Through dialogues with its inhabitants, with the sound and visual mapping of neighbourhoods, we want to understand what areas exist or are necessary for a greater participation or inclusion of urban life; what aspects of the sensitive culture have deteriorated or remain as agglutinators of social life; and what can be done, at the level of acoustic ecology, to maintain an aural experience that brings well-being and identity to the community.
With this project, whose objectives could be applied to other neighbourhoods in the city, we intend to unite an ancestral sensitive culture to the notions of time, space, community and renewed identity, in part, by the use of reproduction technologies.
The works to be developed will be included online in the website Lisbon Sound Map.
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Based on the aural experience in two parishes of the municipality of Lisbon, Alvalade and Belém, we intend to draw the relationship of the communities with their neighbourhood.
Through dialogues with its inhabitants, with the sound and visual mapping of neighbourhoods, we want to understand what areas exist or are necessary for a greater participation or inclusion of urban life; what aspects of the sensitive culture have deteriorated or remain as agglutinators of social life; and what can be done, at the level of acoustic ecology, to maintain an aural experience that brings well-being and identity to the community.
With this project, whose objectives could be applied to other neighbourhoods in the city, we intend to unite an ancestral sensitive culture to the notions of time, space, community and renewed identity, in part, by the use of reproduction technologies.
The works to be developed will be included online in the website Lisbon Sound Map.
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