Targeting β-cell dysfunction as a therapeutic strategy for diabetes: a multi-omics approach
No Acronym
2023.01737.BDANA
FCT
2024-03-01
2028-03-31
Ongoing
The project aims (a) to provide novel insights on the molecular targets and mechanisms underlying β-cell dysfunction, uncovering molecular targets for potentiating transdifferentiation of α-cells to β-cell-like insulin producers, and (b) to explore the beneficial health effects of small molecule (poly)phenol metabolites (SMPM) in modulating these targets to restore metabolic homeostasis.
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