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The HYGIEIA Project aims to bring a ground-breaking educational project providing scientific knowledge and competencies that are applicable in risk prevention (rather than treatment) health strategies. This is achieved through non-pharmacological approaches: Nutrition, Lifestyle education and thoughtful use of Cosmetics, Food Supplements and Digital Tools, accomplishing the potential synergies that can be established when a holistic approach is used. HYGIEIA will involve student mobility in Lusófona University (Portugal), University of Balearic Islands (Spain) and University of Belgrade (Serbia), and multiple opportunities of interaction with industry and stakeholders belonging to its global Associated Partners network.
Ongoing
2028-03-31
2022-01-31
Erasmus +
HYGIEIA
Promoting Health and Well-being across the lifespan
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Red 323RT0142 aims to contribute to economic recovery through scientific-technological cooperation mechanisms associated with the Plant Food Value Chain, focused on fruit and vegetable crops, that provide transferable results. We will work around 5 strategic axes: a-R+D+i; b-Transfer to the productive sector; c-Social Aspects; d-Definition and quantification of indicators, goals and achievements; e-Exploitation, Dissemination and Communication.
Justification: Ibero-America has been one of the regions most affected socially and economically by the pandemic. The Circular Economy is key to designing recovery plans based on the exploitation of our own natural resources. Ibero-America is a region with great diversity of fruit and vegetable crops and its waste (16% of total food waste) offers unique and underexploited opportunities for the recovery of bioactive compounds and use in various co-products.
Ibero-circular is an intersectoral and interdisciplinary consortium with know-how and complementary capabilities that will provide innovative solutions in their added value. A comprehensive approach is proposed that contemplates the recovery/characterization of valuable compounds through green methods, their valorization for the development of sustainable processes and products with high added value for the food, nutraceutical and/or cosmetic sector, together with the reduction of environmental impact. Gender balance and the inclusion of regional communities in the proposed activities are highlighted.
Other participating countries 20 Groups, with a total of 131 Researchers from 8 Ibero-American countries
Past
2026-01-01
2023-01-01
Red 323RT0142
Red Iberoamericana de Innovación para la Sostenibilidad de la Cadena de Valor de Alimentos (ibero-circular)- cyted
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This project explored the role of oxidative stress pathways in cancer progression, particularly in breast, renal, and brain cancers. By analyzing gene expression data from various databases and conducting experiments with cell cultures and human tissue samples, we contributed to understand how specific proteins involved in regulating cellular redox status contribute to cancer development. Additionally, we screened natural compounds to identify potential therapies that target these proteins.
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OLIVE2NEW focuses on an innovative circular bioeconomy approach based on the valorisation of olive tree by-products. The project aims to develop sustainable solutions with potential applications in health, cosmetics, and food-related fields, while simultaneously promoting environmental sustainability, resource efficiency, and technological innovation.
Ongoing
2027-06-30
2026-01-01
https://doi.org/10.62658/COFAC/ILIND/CBIOS/2/2025
Olive2New
Repurposing Olive Oil By-products into Sustainable Health and Nutrition Products
Microalgae are eukaryotic, unicellular and photosynthetic organisms that have great potential for producing fatty acids, pigments such as carotenoids and chlorophyll, as well as other metabolites of interest in the food, pharmaceutical and cosmetics industries. There are few records in the literature showing the use of microalgae in cosmetic preparations, and there is also no information on the safety and efficacy of these products. This project aimed to seek the biotechnological potential of two species of microalgae Neochloris oleoabundans UTEX 1185 and Ankistrodesmus braunni UTEX 245 aiming for their application in the cosmetics industry. Biomass and/or its biocompounds were incorporated into cosmetic formulations. The safety and efficacy of formulations were determined through non-invasive evaluation of the biophysical properties of the skin, conducted through the use of skin bioengineering equipment; and by the in vivo antioxidant/anti-inflammatory activity of cosmetic formulations containing microalgae using a methodology combining the application of methyl nicotinate and Laser Doppler flowmetry.
Past
2017-12-31
2017-01-01
No Acronym
Safety and clinical efficacy of dermocosmetic formulations containing biocompounds obtained from microalgae
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Overexpression of P-glycoprotein (Pgp/ABCB1) in cancer is a marker of overall poor chemotherapy response and prognosis. This computational project builds on previous studies lead by the PI and Co-PI on multidrug resistance (MDR) in cancer by using computational models and simulations for gaining information about the inner dynamics, structural features and drug-Pgp interaction and mode of action.
The human Pgp conformations deposited recently on the Protein Data Bank revealed a new inward facing conformation that may represent either the closing of a gate region or an artifact derived from lateral compression in a too small size nanodisc, used to stabilize the transporter. Using a simpler model, we have done preliminary investigations pointing for the presence of an artifact in the experimental protocol (DOI:10.1101/692988).
However, this hypothesis can only be tested and settled using molecular dynamics simulations at very long time scales with complete atomistic description of the biochemical system, impossible to match using in-house resources. Knowing if there is an artifact on the human structures or if this new structures correspond to a yet to be confirmed meta-stable intermediary state is of capital importance since further computational studies of Pgp can only produce reliable information when using Pgp structures representative of its correct native fold.
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The project aims (a) to provide novel insights on the molecular targets and mechanisms underlying β-cell dysfunction, uncovering molecular targets for potentiating transdifferentiation of α-cells to β-cell-like insulin producers, and (b) to explore the beneficial health effects of small molecule (poly)phenol metabolites (SMPM) in modulating these targets to restore metabolic homeostasis.
Ongoing
2028-03-31
2024-03-01
FCT
2023.01737.BDANA
No Acronym
Targeting β-cell dysfunction as a therapeutic strategy for diabetes: a multi-omics approach
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The TRANSCEND project seeks to address major challenges associated with diabetes through integrated and innovative scientific approaches. By generating new knowledge and exploring novel intervention strategies, the project aims to contribute to improved prevention, diagnosis, and therapeutic solutions, with significant potential clinical and societal impact.
Ongoing
2027-06-30
2026-01-01
https://doi.org/10.62658/COFAC/ILIND/CBIOS/1/2025
TRANSCEND
Transforming Diabetes: Novel Strategies Centered on Pancreatic Cell Plasticity
The development of ceramide-enriched transfersomes may be a valuable strategy for the topical management of inflammatory skin disorders, such as atopic dermatitis and psoriasis. The inflammatory cascade of these diseases leads to the reduction of the ceramide content of the stratum corneum, causing an increase in transepidermal water loss due to the disturbed barrier function. In this sense, ceramide-enriched transfersomes would repair the barrier function of the stratum corneum, as previously demonstrated for ceramide or pseudoceramide-enriched creams. Moreover, the encapsulation of anti-inflammatory drugs in these nanocarriers may improve their transdermal delivery, reducing the need for the systemic application of glucocorticoids with huge costs in terms of toxicity. Understanding the effects of adding ceramides and anti-inflammatory drugs to the bilayer structure of transfersomes is of utmost importance to rationally design these advanced vesicular systems. The main objective of this project is to describe, at a molecular level, the effect of functional excipients and bioactive compounds on the lipid bilayer structure of transfersomes. Various functional ingredients will be studied, namely EAs, ILs, and ceramides, as well as various bioactive compounds with anti-inflammatory properties (glucocorticoids and phytochemicals). These studies will be of upmost importance to optimize innovative transfersomal formulations for (trans)dermal applications.
Past
2022-02-28
2021-11-01
No Acronym
Understanding transfersomes’ structure to conquer (trans)dermal drug delivery
