Identification of emerging risks associated with food supplements, other than vitamins and minerals
No Acronym
2024-01-01
2026-06-22
Past
The PT -ASAE authority has consistently gathered and provided data on the safety of plant-based food supplements marketed in Europe and cooperated through Briefing Notes to its discussion as an issue of concern since the creation of EFSA (see Botanicals | EFSA (europa.eu)), and during the Emerging Risks Exchange Network (EREN) meeting in April 2021. Thus, it is greatly welcome the opportunity EFSA launched to a project for an outsourced activity that was developed by the SCER/KNOW Secretariat included under NEXT Programme, further endorsed at the Advisory Forum (AF) in March 2023.
After the kick-off meeting on 29th January, the PT -ASAE Group is actively focused on contributing to the establishment of a topic community of knowledge on food supplements, in strategic partnership, engaging with expertise for signals in nutrivigilance systems and for analyzing plant-based substances of concern.
It is also clear that the community’s role is to identify possible emerging risks without mandate to conduct risk assessment as per Regulation (EC) 178/2002 or Reg. (EC) 1925/2006.
Task 1 - Work Package 1: Establishment and moderation of Community of Knowledge on food supplements other than vitamins and minerals
Task 2 - Work Package 3: Identifying potentially hazardous food supplements, other than vitamins and minerals, containing plant-based substances with predicted toxicity in the EFSA Compendium on Botanicals
Agence Nationale De Sécurité Sanitaire De L'alimentation, De L'environnement Et Du Travail
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IM Lab (Intersectionality Media Lab) - The Joacine Katar Moreira Case study
IM Lab
CICANT/Researcher/2020
Institutional Funding
2021-04-01
2022-09-30
Past
This project aims to analyse the media coverage of the first six months of the parliamentary term of Joacine Katar Moreira, the first racialized woman, head of the list of a political party in Portugal, covering her initial path, first as representative elected for the LIVRE party, then as non-attached member.
The goal is that this project be the first contribution for the creation of the IM Lab - Intersectionality Media Lab, integrated in ReLeCo Media Society and Literacies of CICANT. The study of intersectionality is deemed “relevant as a way of approaching the media construction of the society and its impacts on the deconstruction or sedimentation of power relations, in the individuals’ experiences and subjectivities” (Cerqueira e Magalhães, 2017: 15). The purpose is that IM Lab stands as a specialized academic laboratory, engaged with the production and dissemination of knowledge, in line with the objectives of CICANT, which may become an enriching partner of the existing MeLCi Lab.
This project aims to promote the inclusion of deaf children in pre-school through a bilingual glossary accessible to deaf and hearing people. This first prototype integrates 20 to 30 fundamental mathematical terms in a form of a bilingual hybrid (digital & tangible) game aimed at deaf and hearing children of preschool and 1st year of basic education; will be a combination of physical pieces with LGP video and graphics animation correspondence, that will be visible on a mobile phone or/and in a stand-alone physical object. The project has as its starting point a rudimentary glossary in Power Point format developed in the past by LUDUS and CED - Jacob Rodrigues Pereira for use by teachers at this school. Moreover, GIM has the following objectives:
- Produce and validate an useful, fun and engaging bilingual LGP glossary-game prototype for the preschool and 1st year of basic education, that can be adopted by educators, children and families of deaf children;
- Contribute to improve the conditions of learning mathematics in deaf students, as well as their educational inclusion;
- Produce and validate an instrument for difference awareness to be used in regular schools;
- Establish the bases for future funding applications that allow the project to scale up in terms of glossary improvement and expansion, evaluation sample, as well as its dissemination in the deaf community and Reference Schools for Bilingual Education of Deaf Students (EREBAS).
- Introduce international partnerships based on a transnational problem.
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BEING was a project from COPELABS dedicated to exploratory research activities in the context of mobile crowd sensing. In BEING we rely on middleware developed in the COPELABS CitySense (2012-2017) project and focus on contextualization derived from data captured via wireless networks, and which today any device overhears. BEING expects to contribute to the development of pervasive wireless solutions, as well as studies in mining in wireless networks, to assist in a better and non-intrusive inference of human behavior, from an individual and collective perspective.
BEING considers behaviour inference to be a product of three main aspects: I) passive sensing (roaming context); ii) routine and activities (human context); iii) and contextual information (affinities and similarities). Such behavior inference is to be performed with the owners of sensorial devices being agnostic and not disturbed with any sensing activities, and focusing on adequate activity classification modeling, considering models which can incorporate sensing fusion (more than one sensor and the data correlation towards the prediction of e.g., activities).
In order to target the most important challenges of devising large-scale personal sensing systems, this project aims to investigate and develop a pervasive wireless sensing framework able of leveraging cooperative sensing, data and context gathering. In the proposed framework, only people with strong similarities share training data: a wide range of affinity networks (e.g., proximity networks, online social networks, conversation networks) indicates different typesof interpersonal similarities. The proposedframework will make use of these different networksto determine an affinity graph that quantifies the similarity betweenusers, identifying opportunitiesfor effective sharing.
Inhibition of intracellular Ca2+ channels as a strategy to control glioma
Ca2GB
COFAC/ILIND/CBIOS/4/2024
2025-07-01
2026-12-31
Ongoing
Tumours of the brain and nervous system (BNS) represent a particular diagnosis and therapeutical challenge. The estimated cumulative risk of mortality associated with BNS cancers is particularly high in countries such as Portugal and Brazil. BNS cancers rank 8th and 9th in the list of cancers with higher mortality in Portugal and Brazil, respectively. The poor survival rate of glioma patients is mostly attributed to the high genetic heterogeneity and invasive properties of the tumour. Inevitably, this leads to invasion of adjacent tissues and resistance to the therapies. Tumour invasion is a key hallmark of high-grade gliomas such as glioblastoma (GB) and a determinant for patient outcome. The current therapies rarely result in remission or meaningful improvement of life expectancy. Therefore, the development of alternative therapeutic approaches against gliomas is urgent. Despite this, no approved drugs target cell invasion.
Calcium ion (Ca2+) signalling dynamics and subcellular localization are tightly regulated. The dysregulation of Ca2+ homeostasis is crucial in cancer initiation and progression. Cancer cells can establish cancer hallmark features, by manipulating the expression or activity of Ca2+ modulators, including pumps, channels, and exchangers. Thus, our main goal is to explore the modulation of intracellular Ca2+ fluxes as a therapeutic strategy to inhibit glioma progression.
As an innovative approach, we propose to reprogram Ca2+ intracellular fluxes/homeostasis by inhibiting specific endoplasmic reticulum (ER) or Golgi apparatus (GA) Ca2+ channels to control glioma progression. Ca2+ release to the cytoplasm can control processes essential for glioma progression. Increasing evidence associates intracellular Ca2+, redox and thiol homeostases with glioma progression. The mechanisms linking these key aspects of glioma cell biology and how they impact cell invasion or proliferation are unclear and no approved glioma therapeutics target these processes. We propose to modulate the activity of specific intracellular ER and GA Ca2+ channels to control glioma progression.
As proof of principle, we demonstrated that manipulating the GA Ca2+ channel TMBIM4 expression impacts glioma cell invasion and in vivo tumour growth. We herein propose to identify other ER and GA Ca2+ channels that affect glioma progression and to find pharmacological inhibitors to TMBIM4.
To identify the first inhibitors of the GA Ca2+ channel TMBIM4, a virtual screening will be conducted from libraries of compounds that will include natural compounds and derivatives. The impact of the identified molecules on GB 3D invasion and redox status will be evaluated in vitro.
The search for additional ER and GA Ca2+ channels that may constitute therapeutic targets will start with a bioinformatic approach based on glioma gene expression and patient survival data, to identify those associated with glioma patient outcome. The effects of expression manipulation of identified channels on cell viability, proliferation, invasion, and redox status will be analysed. To survive in adverse conditions, cancer cells undergo deep metabolic reprogramming. Here, thiol homeostasis the availability of cysteine are central for glioma progression. Searching for additional mechanistic clues, we propose to identify the subset of ER and GA Ca2+ channels that act on glioma cell phenotype in a cysteine-dependent manner. Here, our findings will break the ground on the combined effects of Ca2+ intracellular fluxes deregulation and cysteine availability in glioma.
This project will allow the identification of drug-like copounds able to inhibit TMBIM4, which could constitute potential drugs and mechanistic tools for cell biology studies, and the identification and validation of additional ER or GA Ca2+ channels that affect glioma progression. The data generated will pave the way for subsequent lines of research in pharmacology and drug delivery systems against glioma invasion.
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Innovative skin products from the valorization of industrial marine wastes
Blue4Skin
2023-01-01
2024-12-31
Past
The Blue4Skin project intends to use sardine co-products, from the company “Conservas Pinhais & Cia” in order to be used as raw materials in innovative health products for the skin, with added value. The optimization of extraction, fractionation, isolation and identification of marine natural products and the corresponding screening study of various bioactivities related to skin health is important to enable the use of these residues and co-products and ensure the safety, quality, and acceptability of the product. It is also intended to contribute to the mitigation and adaptation to climate change through the reduction of waste from these industries. Thus, the exploitation of marine biomass and recovery of sea co-products seems to be a promising alternative to sustainable uses of marine resources with greater economic benefits, in line with the concepts of circular economy and blue bioeconomy.
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Integrated Multi-Omics for Novel Diabetes Biomarkers Targeted by (Poly)phenol Metabolites
No Acronym
2023-03-15
2023-09-15
Past
The project explores existing multi-omics datasets associated with powerful bioinformatic tools to identify novel molecular targets associated with α- to β-cell-like transdifferentiation. In combination with multigenomic data from small molecule polyphenol metabolites (SMPM) studies, the project aims to facilitate the advancement of these small molecules into lead candidates for nutraceutical and pharmaceutical applications in diabetes management.
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The IoT Lab is an operational team of COPELABS that works on networking architectures and communication protocols for multiple IoT environments, e.g., personal IoT and industrial IoT. A few aspects being worked upon concern protocolar transmission and unified abstraction models for edge computing, as well as the relevancy of novel communication models (e.g., ICN) for IoT.
Internet of Things (IoT) communication architectures and protocols are evolving to be able to cope with new challenges such as the processing of large amounts of data; filtering; data mining and classification; high heterogeneity in devices and software.
Today, IoT communication is supported by TCP/IP which were not designed having in mind time sensitive networks or low power networks. Energy is wasted each time data is transmitted, due to protocol overhead, and non-optimized communication patterns. The most recent trend on communication protocols follow a publish/subscriber broker approach, which creates an abstraction between things that produce information, and people or devices that consume such information. Nevertheless, issues concerning mobility management, privacy, security, and resource consumption subsist mostly tied to the networking semantics of IP, which follow a host-based reachability approach. The new architectural paradigm of ICN focuses on providing support to directly reach information objects, while in contrast today’s Internet is focused on reaching devices that store information objects. The design of ICN paradigms seem to bring in relevant features to IoT environments. ICN approaches such as NDN have integrated security support; reliable multi-path data-based routing; built-in mobility support such as an interface abstraction, which is relevant for multihoming. Being information-centric, ICN does not transmit data based on host identifiers, such as addresses. The evolutionary trend and interoperability aspects of publish/subscriber approaches as well as of network architectures and protocols in general are being exploited by the COPELABS IoT Lab team.
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LIFEstyle Strategies to Tackle cardiovascular and metabolic Risk
LIFESTAR
https://doi.org/10.62658/COFAC/ILIND/CBIOS/2/2024
2025-09-01
2027-03-14
Ongoing
Non-communicable diseases (NCDs) are among the most pressing global public health challenges. Cardiovascular diseases (CVD) are the leading cause of death worldwide, while metabolic disorders such as obesity and type 2 diabetes mellitus (T2DM) significantly reduce quality-adjusted life years (QUALYs). Adopting healthy lifestyles—particularly regarding nutrition and physical activity - is critical for disease prevention and health promotion across the lifespan. However, the real-world impact of such interventions in at-risk populations remains underexplored.
This pilot project aims to evaluate the effects of simple lifestyle changes - focusing on diet quality and physical activity - on cardiovascular and metabolic risk markers in sedentary adults.
The study will recruit 60 omnivorous men and women over 40 years old, presenting with overweight or obesity and a sedentary lifestyle. Participants will undergo comprehensive baseline assessments, including body composition via dual-energy X-ray absorptiometry (DXA), anthropometric measurements, dietary intake using the Diet Quality Index-International (DQI-I), and physical activity levels via the International Physical Activity Questionnaire (IPAQ). Fasting capillary blood samples will be used to assess key metabolic biomarkers. Hemodynamic and vascular health will be evaluated non-invasively through ankle-brachial index (ABI) calculations and assessments of lower limb perfusion asymmetries. Risk stratification will include the SCORE2® algorithm to estimate 10-year cardiovascular risk and the FINDRISC tool for T2DM risk. Participants will be grouped accordingly at baseline.
The intervention will involve small dietary modifications aligned with Portuguese national guidelines, alongside a minimally supervised home-based physical activity program designed by our team, following the FITT (Frequency, Intensity, Time, and Type) principle. The program is intended for daily completion at each participant's convenience. Data will be collected at baseline and at 1, 3, and 6 months. The primary goal is to improve metabolic and cardiovascular profiles, ultimately reducing long-term CVD and T2DM risk. This project will provide evidence that accessible, consistent lifestyle changes can meaningfully improve health and well-being.
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